Supported by an unrestricted educational grant from AstraZeneca and Ultromics
Radcliffe Documentaries

Part one: 5 chapters · 59 min

Part one coming soon

diagnosis

Why ATTR cardiac amyloidosis is missed, what it does to the heart, and the signs that should prompt a second look.

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  1. 01Not rare: missedWho does ATTR affect, and why does it hide in plain sight?12 min

    Clinicians and patients set out the scale of the problem: a disease long thought rare that is now found in heart failure, aortic stenosis and orthopaedic clinics.

    Featuring

    • Dr Firstname LastnameCardiologist, amyloidosis centre
    • Firstname LastnamePatient, living with hereditary ATTR
  2. 02The proteinHow does transthyretin come apart and build amyloid in the heart?9 min

    The TTR tetramer falls apart, the units misfold and stack into fibrils between heart muscle cells.

    Chapter coming soon

    Featuring

    • Dr Firstname LastnameCardiologist, amyloidosis centre
    • Dr Firstname LastnamePathologist
  3. 03The missed yearsWhy is ATTR diagnosed late, and what does it cost?14 min

    Carpal tunnel and spinal stenosis can come years before the heart. Every year before diagnosis is a year of progression.

    Chapter coming soon

    Featuring

    • Firstname LastnamePatient, living with ATTR
    • Dr Firstname LastnameCardiologist
    • Dr Firstname LastnameHeart failure specialist

    Chapter three downloads

    • Chapter summaryComing soon
    • Key slidesComing soon
    • ReferencesComing soon
    • TranscriptComing soon
  4. 04The red flagsWhich signs should prompt a second look?11 min

    A thick wall with low voltages, an intolerance to standard heart failure drugs, a history in the hands and spine.

    Chapter coming soon

    Featuring

    • Dr Firstname LastnameCardiologist, cardiac imaging
    • Dr Firstname LastnameCardiologist

    Chapter four downloads

    • Chapter summaryComing soon
    • Key slidesComing soon
    • ReferencesComing soon
    • TranscriptComing soon
  5. 05Making the diagnosisHow is ATTR confirmed without a biopsy?13 min

    Bone scintigraphy can confirm ATTR once light-chain amyloid is ruled out. Genetic testing separates wild type from hereditary.

    Chapter coming soon

    Featuring

    • Dr Firstname LastnameCardiologist, cardiac imaging
    • Dr Firstname LastnamePathologist

    Chapter five downloads

    • Chapter summaryComing soon
    • Key slidesComing soon
    • ReferencesComing soon
    • TranscriptComing soon

Part one resources

  • Full slide kitComing soon
  • Discussion guideComing soon
  • Red flags cardComing soon
  • Diagnostic pathwayComing soon
  • All referencesComing soon

In this part

  • Dr Firstname LastnameCardiologist, amyloidosis centre
  • Firstname LastnamePatient, living with hereditary ATTR
  • Dr Firstname LastnamePathologist
  • Firstname LastnamePatient, living with ATTR
  • Dr Firstname LastnameCardiologist
  • Dr Firstname LastnameHeart failure specialist
  • Dr Firstname LastnameCardiologist, cardiac imaging

Credits

Presented by
Radcliffe Documentaries
Produced by
Made Clear Studios
Directed by
To be confirmed
Motion graphics and 3D
Radcliffe creative team
Medical review
To be confirmed
Music and sound
To be confirmed

Supported by an unrestricted educational grant from AstraZeneca and Ultromics